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The McCray Lab

Investigating mechanisms of hereditary neuromuscular disease

Who we are and what we do

Brett A. McCray, MD, PhD, is a physician scientist who leads a basic, translational, and clinical research program and also sees patients with neuromuscular disease. Dr. McCray is an Assistant Professor at the University of Michigan leading a research group focusing on furthering the understanding and treatment of peripheral neuropathy, particularly inherited forms of peripheral neuropathy such as Charcot-Marie-Tooth (CMT) disease. The lab is primarily focused on inherited neuropathy caused by mutations in TRPV4 (transient receptor potential vanilloid 4) that cause a range of conditions including CMT type 2C, scapuloperoneal spinal muscular atrophy, and congenital distal spinal muscular atrophy.

The McCray Lab combines the study of cultured cells and analysis of animal models of disease to elucidate pathways important in the pathogenesis of TRPV4 neuropathy and other forms of neuropathy. The lab is also involved in clinical and translational research efforts to help bring insights from the bench to patients affected by various forms of hereditary neuropathy, with a particular focus on TRPV4 channelopathies. 

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